Elucidating protein

Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.

Their diverse biological activities are derived from an ability to regulate a remarkable number of proteins.

The ubiquitin-editing enzyme A20 maintains transient NF-κB activation by opposing the K63-linked polyubiquitination of RIP1 and TRAF6.

For example, the radius was systematically increased, moving the analysis beyond local alpha-carbon neighborhoods in order to capture super-secondary and tertiary structures.

Notably, loss-of-function somatic mutations or polymorphisms in human A20 are associated with B-cell lymphomas or a variety of autoimmune diseases as a result of dysregulated NF-κB activation.

In this chapter, we summarize the protocols routinely used in our laboratories to examine ubiquitination and NF-κB signaling.

Together, our combined microarray and computational modeling methodologies provide a general, facile means to identify new glycosaminoglycan–protein–protein interactions, as well as a molecular-level understanding of those complexes.

Transcription factors recruit a wide variety of associated co-factors to regulate gene expression.

Search for elucidating protein:

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Our studies show for the first time that CS is capable of assembling multimeric signaling complexes and modulating neurotrophin signaling pathways.

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  1. Pat sat me down for hours upon hours just going through the playbook just to go to practice the next day. I owe big dividend to Pat.” To think, Wilson was there to essentially replace Tillman.